# gangrene

/ˈɡænɡɹin/ (US) · /ɡˈæŋɡɹiːn/ (UK) · CEFR C2 · Noun

Source: https://englishreference.com/word/gangrene
Updated: 2026-10-13

## Definition

the death of body tissue, usually because the blood supply has stopped or there is a serious infection. It often affects the toes, fingers, or limbs and can be very dangerous if not treated.

For teachers: the localised death and decomposition of body tissue, resulting from either obstructed circulation or bacterial infection. Often categorised into dry, wet, or gas varieties depending on the underlying cause and presence of infection.

## Examples

- The doctor treated the wound quickly to prevent gangrene.
- If a deep wound is left untreated and becomes infected, gangrene can set in, potentially leading to the need for amputation.
- Historically, battlefield surgeons feared gangrene more than the initial trauma, as the lack of antibiotics meant that even minor shrapnel wounds could lead to rapid tissue necrosis and systemic sepsis.

## Usage notes

- Commonly used with the verbs 'set in' or 'develop'.

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