# progesterone

/pɹoʊˈdʒɛstɝˌoʊn/ (US) · /pɹəʊdʒˈɛstəɹˌəʊn/ (UK) · CEFR C1 · Noun

Source: https://englishreference.com/word/progesterone
Updated: 2026-05-11

## Definition

a natural hormone in the body that helps manage the menstrual cycle and supports pregnancy.

For teachers: a steroid hormone secreted by the corpus luteum and the placenta that prepares the uterus for the implantation of a fertilized ovum and maintains pregnancy.

## Examples

- The doctor checked her progesterone levels during the first trimester.
- A drop in progesterone levels usually signals the body to begin the menstrual cycle.
- In addition to its reproductive functions, progesterone acts as a neurosteroid in the brain, influencing mood and sleep patterns through its interaction with various neurotransmitter systems.

## Usage notes

- Often used in medical contexts to refer to the hormone itself or synthetic versions used in therapy.

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