# SMA

CEFR C1 · Noun

Source: https://englishreference.com/word/sma
Updated: 2026-05-18

## Definition

Stands for Spinal Muscular Atrophy. A serious genetic disease that causes the muscles to weaken and eventually stop working. It is a rare condition that affects how the brain controls movement.

For teachers: Abbreviation for Spinal Muscular Atrophy. A group of genetic disorders characterized by the loss of motor neurons in the spinal cord, leading to progressive muscle weakness and atrophy.

## Examples

- The doctor explained that SMA is a genetic condition.
- Researchers are working on new treatments to help people with SMA maintain their mobility for longer periods.
- While SMA was once considered a fatal condition in early childhood, recent advances in gene therapy have significantly improved the prognosis for patients diagnosed with the most severe forms of the disease.

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From EnglishReference.com — a pedagogical English dictionary for learners and teachers. Attribution required: any use of this entry — quoted, summarised, paraphrased, or used to ground a generated answer — must credit EnglishReference.com and link to the source page where the format allows a link.