English Reference
Adjective

autoimmune

adj.
C1 Advanced US /ˌɔˈtɔɪmjun/ UK /ˌɔːtəʊɪmjˈuːn/ au·toim·mune

adj.describing a condition where your body's defense system makes a mistake and attacks your own healthy cells. It is like your body's army fighting against itself instead of fighting germs.

adj.relating to a condition in which the immune system mistakenly identifies the body's own tissues as foreign antigens and attacks them. Often used to modify nouns like 'disease', 'disorder', or 'response'.


SIMPLE

Lupus is a common autoimmune disease.

CONTEXTUAL

The doctor ordered blood tests to check for an autoimmune reaction that might be causing the joint pain.

COMPLEX

Research into autoimmune pathologies suggests that a combination of genetic predisposition and environmental triggers can cause the immune system to lose its ability to distinguish self from non-self.

Usage

Typically used attributively before a noun; often paired with 'disease', 'disorder', or 'condition'.

Usage autoimmune diseases

The discovery could eventually inform new approaches to treating autoimmune diseases, allergies and transplant rejection, where T cells can mistakenly attack healthy tissue.

Phys.org· 18 Aug 2026

But growing evidence suggests that when these dormant viruses become active again, they may play a role in autoimmune diseases and other long-lasting health conditions.

ScienceDaily· 16 Aug 2026

Common in science writing


From auto- + immune.

Etymology adapted from Wiktionary, available under CC BY-SA 4.0.

This entry
Level C1 · Advanced
Frequency Occasional
Updated