English Reference
adjective

deleterious

adj.
US /ˌdɛɫəˈtɪɹiəs/ UK /dɪlɪtˈiəɹɪəs/ dele·te·ri·ous

  1. 01 C1 Advanced FormalAcademic

    harmful to someone or something, often in a slow or hidden way.

    causing harm or damage, particularly in a subtle, cumulative, or unexpected manner.

    Simple

    Smoking has a deleterious effect on your long-term health.

    In context

    The new policy had a deleterious impact on staff morale, leading to a significant decrease in productivity over the following quarter.

    Usage

    Frequently used in the phrase 'deleterious effect' or 'deleterious impact'.

    Teacher's tip

    This is a high-level academic synonym for 'harmful'; students should use it in formal essays rather than casual conversation.

  2. 02 C2 Proficiency TechnicalAcademic Science

    describing a gene or trait that makes a living thing less healthy or less likely to survive.

    reducing the biological fitness of an organism; specifically used for mutations that are harmful to survival or reproduction.

    Simple

    The animal carried a deleterious mutation that made it difficult to find food.

    In context

    Natural selection typically acts to remove deleterious alleles from the population, though some may persist in recessive forms.

    Usage

    Commonly modifies nouns like 'mutation', 'gene', or 'allele'.

    Teacher's tip

    This sense is specific to biology and genetics; it is rarely encountered outside of scientific literature.

    maladaptive

Usage deleterious effect

The powerless conditions have led to food lines, closed businesses, dead phones, no schools, spoiled food, dirty clothes, dry gas pumps and a multitude of other deleterious effects on life without energy.

The Guardian· 22 Aug 2026

But I have had an at best ambivalent – and at worst deleterious – relationship with two social media platforms that I’ve had to quit cold turkey.

The Guardian· 3 Aug 2026

Adapted borrowing (1640s; 1582 as deletorious) of New Latin dēlētērius, dēlētōrius + -ous, from Ancient Greek δηλητήριος (dēlētḗrios, “noxious, deleterious”), from δηλητήρ (dēlētḗr, “a destroyer”), from δηλέομαι (dēléomai, “I hurt, damage, spoil, waste”). Not related to delete or deleble. Doublet of deletery.

Etymology adapted from Wiktionary, available under CC BY-SA 4.0.

This entry
Origin Ancient Greek δηλητήριος
Level C1 · Advanced
Frequency Occasional
Updated