English Reference

Word

histone

Phoneticshi·s·tone

Definition

n. a protein that helps hold DNA together in a neat, organized shape inside your cells. It acts like a spool that DNA wraps around to keep it from getting tangled.

n. a protein that provides structural support for the DNA in eukaryotic cells. These proteins form the core of nucleosomes, around which the DNA double helix is wound to facilitate compaction and gene regulation.

Examples

“The DNA wraps around a histone to stay organized.”

“Changes in the chemical tags on a histone can affect how tightly the DNA is packed, which in turn controls which genes are active.”

“Epigenetic modifications to the histone tails can alter the accessibility of the underlying DNA, effectively turning genes on or off without changing the actual sequence of the genetic code.”

Examples

simple

“The DNA wraps around a histone to stay organized.”

contextual

“Changes in the chemical tags on a histone can affect how tightly the DNA is packed, which in turn controls which genes are active.”

complex

“Epigenetic modifications to the histone tails can alter the accessibility of the underlying DNA, effectively turning genes on or off without changing the actual sequence of the genetic code.”

Real-World Examples

“Acetyl-CoA also interacts with histones, spool-like proteins around which DNA is wrapped.”
ScienceDaily · 14 Sept 2026
“DNA is wrapped around proteins called histones, which help control how tightly or loosely it is packed.”
ScienceDaily · 26 Aug 2026

Etymology

Borrowed from German Histon, perhaps from Ancient Greek ἵστημι (hístēmi, “make stand”) or ἱστός (histós, “loom”).

Etymology adapted from Wiktionary, available under CC BY-SA 4.0.

This entry

Level
C1 · Advanced
Frequency
Occasional
Updated

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English Reference