English Reference

Word

pox

US/ˈpɑks/

UK/pˈɒks/

Definitions

01a skin disease

C1 · Medicine

n. a disease that causes small, painful spots or marks on the skin.

n. any of several viral diseases characterized by purulent skin eruptions that often leave permanent pockmarks.

“In the past, many children suffered from the pox before vaccines were common.”

“Historical records indicate that the pox decimated the local population long before modern medical interventions were available.”

Archaic

Usage

Often used as a suffix in modern English, such as 'chickenpox' or 'smallpox'.

Synonyms

02a curse

C2

n. a way to wish bad luck or illness on someone.

n. a curse or imprecation, most famously used in the idiom 'a pox on both your houses'.

“He shouted 'a pox on you' when he lost the argument.”

“The character delivers a bitter monologue, wishing a pox upon his enemies for their perceived betrayal.”

Literary · Archaic

Teaching tip

This sense is almost exclusively found in Shakespearean literature or humorous, mock-archaic speech today.

Synonyms

cursemalediction

Antonyms

03to infect

C2

v. to give someone a disease that causes skin spots.

v. to infect a person with a pox-like disease, particularly syphilis in historical contexts.

“The old story tells of a man who was poxed after his travels.”

“The satirical poem describes a city where half the inhabitants were poxed by their own vices.”

Archaic · Formal

Usage

Usually appears in the passive voice as 'to be poxed'.

Antonyms

Real-World Examples

“Infected animals are left covered in characteristic pox scars.”
Phys.org · 25 Sept 2026
“A fresh outbreak of mpox in Guinea Bissau – the country’s first – means the virus formerly known as monkey pox is back in the headlines.”
The Guardian · 26 Aug 2026

Etymology

From the plural of Middle English pocke. See also pock.

Etymology adapted from Wiktionary, available under CC BY-SA 4.0.

Word family

poxNounsmallpoxNoun

This entry

Level
C2 · Proficiency
Frequency
Occasional
Updated

Scan code

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English Reference