restlessness
n. uncountable B2 Upper Intermediate US //ˈɹɛstɫəsnəs// UK //ɹˈɛstləsnəs// rest·less·ness
n. a feeling of being unable to stay still or relax. It often makes you want to move or do something, even if you are tired.
n. a state of physical or mental unease that prevents relaxation or rest. Often associated with an inability to remain in one place or a constant desire for change.
The long flight made him feel restless and tired.
After working in the same office for ten years, she felt a growing restlessness and decided to look for a new job.
The protagonist's restlessness is a central theme of the novel, driving him to seek out distant lands despite the comfort and security of his current home.
From restless + -ness.