The loss of their main sponsor was a real body blow.
body blow
idiomA serious setback; a traumatizing event which prevents or hinders continuation of an activity.
Losing the championship game after such a long season was a major body blow to the team's morale.
The sudden cancellation of the project served as a devastating body blow to the department, effectively halting all progress on their research for the remainder of the year.
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blow a fuse
To lose one's temper; to become enraged.
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blow a hole through
To destroy the integrity or cohesion of.
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blow a kiss
To kiss one's own hand, then blow on it in a direction towards the recipient.
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blow away
To kill (someone) by shooting them with a firearm.
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blow chunks
To vomit chunks of undigested food.
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blow hot air
To engage in empty or exaggerated talk that lacks substance, credibility, or truth; to bluster.
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blow hot and cold
To behave inconsistently; to vacillate or to waver, as between extremes of opinion or emotion.
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blow me
An expression of discontent or aggravation to another party (with a metaphorical connotation of fellatio).