English Reference

Word

atherosclerosis

Phoneticsath·er·o·scle·ro·sis

US/ˌæθɝoʊskɫɝˈoʊsɪs/

UK/ˌæθəɹˌɒskləɹˈəʊsɪs/

Definition

n. a medical condition where the walls of your arteries become thick and stiff. This happens because of a build-up of fat and other substances, which can make it harder for blood to flow through your body.

n. a chronic inflammatory disease of the arteries characterised by the accumulation of fatty plaques within the arterial walls. This process leads to the narrowing and hardening of the vessels, potentially resulting in reduced blood flow and increased cardiovascular risk.

Examples

“High cholesterol levels are a major risk factor for atherosclerosis.”

“The doctor explained that atherosclerosis in the coronary arteries can eventually lead to a heart attack if left untreated.”

“While atherosclerosis is often associated with aging, lifestyle factors such as smoking, poor diet, and lack of exercise can significantly accelerate the progression of the disease in younger populations.”

Examples

simple

“High cholesterol levels are a major risk factor for atherosclerosis.”

contextual

“The doctor explained that atherosclerosis in the coronary arteries can eventually lead to a heart attack if left untreated.”

complex

“While atherosclerosis is often associated with aging, lifestyle factors such as smoking, poor diet, and lack of exercise can significantly accelerate the progression of the disease in younger populations.”

Real-World Examples

“Researchers have designed a new DNA-based treatment that targets PCSK9, a protein closely tied to high LDL cholesterol and atherosclerosis.”
ScienceDaily · 10 Sept 2026
“There’s a condition called atherosclerosis, where cholesterol, fat and calcium build up into plaque on artery walls, restricting blood flow.”
The Guardian · 11 May 2026

Etymology

From athero- + sclerosis.

Etymology adapted from Wiktionary, available under CC BY-SA 4.0.

Word family

atherosclerosisNounsclerosisNoun

Domains

BiologyMedicine

This entry

Level
C1 · Advanced
Frequency
Occasional
Updated

Scan code

englishreference.com/q/atherosclerosis

English Reference