English Reference
Noun

nucleotide

n.
C1 Advanced US /ˈnukɫiəˌtaɪd/ UK /njˈuːklɪˌɒtaɪd/ nu·cleo·tide UK spelling nucleotide's, nucleotide's

n.a small chemical unit that is the basic building block of DNA and RNA. These units join together to form the long strands that carry genetic information.

n.a monomer consisting of a nitrogenous base, a sugar, and a phosphate group, which serves as the fundamental unit of nucleic acids. Each nucleotide contributes to the genetic code through its specific base pairing.


SIMPLE

Each nucleotide contains a sugar, a phosphate, and a base.

CONTEXTUAL

Scientists identified a specific nucleotide sequence that was responsible for the mutation in the virus.

COMPLEX

The precise arrangement of nucleotides along the DNA helix determines the genetic instructions for protein synthesis and cellular function.

This process relies on a continuous supply of molecular building blocks, specifically pyrimidine nucleotides.

Phys.org· 8 Sept 2026

A major factor determining its stability is the poly(A) tail, a stretch of adenine nucleotides at the end of the molecule.

Phys.org· 14 Aug 2026

From nucleo- (“relating to the nucleus”) + -ide (“chemical suffix”).

Etymology adapted from Wiktionary, available under CC BY-SA 4.0.

This entry
Level C1 · Advanced
Frequency Occasional
Updated