twist of fate

fucked by the fickle finger of fate

Victimized by bad luck.

get one's knickers in a twist

To become overwrought or unnecessarily upset over a trivial matter.

leave someone to their fate

to abandon; to give up on; to leave on their own – chiefly in regard to avoid upcoming misfortune

tempt fate

To take a risk.

twist in the wind

To be unassisted and without comfort in a situation likely to result in distress or failure.