English Reference
verb · noun · adjective

isolate

v. · n. · adj.
US /ˈaɪsəˌɫeɪt/ iso·late UK spelling isolates

  1. 01 B2 Upper Intermediate

    v.to separate one person or thing from a group so they are alone.

    v.to set apart or detach an individual or object from others to prevent contact or influence.

    Simple

    The high mountains isolate the small village from the rest of the country.

    In context

    The political crisis served to isolate the regime from its former allies, leaving the leadership with few diplomatic options.

    Usage

    Often used in the passive voice to describe a state of being alone.

    separatedetachsegregate
  2. 02 B2 Upper Intermediate Medicine

    v.to keep a person or animal away from others to stop a disease from spreading.

    v.to place an individual in quarantine or medical isolation to prevent the transmission of infectious agents.

    Simple

    The hospital had to isolate the patient to prevent the virus from spreading to others.

    In context

    Public health protocols required the authorities to isolate any passengers displaying symptoms of the new strain upon arrival.

    quarantinesequester
  3. 03 C1 Advanced TechnicalAcademic Science

    v.to separate a single substance or chemical from a mixture to get it in a pure form.

    v.to separate a specific substance, chemical, or microorganism from a complex mixture or culture.

    Simple

    Scientists were able to isolate the gene responsible for the plant's color.

    In context

    The laboratory succeeded in isolating the active compound from the rare tropical bark, allowing for further pharmacological testing.

    Usage

    Commonly takes a direct object representing the substance being purified.

  4. 04 C2 Proficiency TechnicalAcademic

    n.a person or thing that has been separated from a larger group.

    n.an individual, population, or substance that has been separated or exists in isolation.

    Simple

    The researcher studied a specific isolate of the bacteria found in the soil.

    In context

    The study focused on a genetic isolate within the island population that showed unique resistance to the local climate.

  5. 05 C2 Proficiency Literary

    adj.being alone or separated from others.

    adj.existing in a state of isolation; solitary or detached.

    Simple

    He lived an isolate life in a cabin deep in the woods.

    In context

    The poet described the isolate peak of the mountain, standing far above the clouds in silent majesty.

Usage isolate the sick · isolate effect · isolate from

The development would in effect divide the West Bank in two and isolate East Jerusalem.

BBC News· 20 Aug 2026

This will be an ECONOMIC D-DAY, and we need all of our Allies to stand with the United States of America to isolate, and defeat, the Iran threat,” he wrote.

Al Jazeera· 19 Aug 2026

Back-formation from isolated, from French isolé, from Italian isolato, from Latin īnsulatus (whence also insulate), see -ate (etymology 1, 2 and 3).

Etymology adapted from Wiktionary, available under CC BY-SA 4.0.

This entry
Origin Latin īnsulatus
Level B2 · Upper Intermediate
Frequency Frequent
Updated