English Reference
adjective

systemic

adj.
US /sɪˈstɛmɪk/ UK /sɪstˈɛmɪk/ sys·temic

  1. 01 C1 Advanced Academic

    affecting an entire organization, society, or system rather than just one part.

    embedded within and spread throughout an entire system, group, or society. Often used to describe structural problems like bias or economic failure.

    Simple

    The company needs to fix systemic problems that cause delays in every department.

    In context

    Economists warned that the failure of a major bank could lead to systemic risk across the global financial market.

    Usage

    Usually placed before the noun it modifies.

    Pitfall
    The computer had a systemic error. The computer had a systematic error.

    Use 'systemic' for something that affects the whole system; use 'systematic' for something done according to a fixed plan or method.

  2. 02 C1 Advanced Technical Medicine

    affecting your whole body through the blood, rather than just one spot.

    relating to the entire body or organism as a whole. In medicine, it describes treatments or diseases that travel through the bloodstream to reach all organs.

    Simple

    The doctor prescribed a systemic medication to treat the infection throughout his body.

    In context

    While a cream treats the skin locally, a systemic antibiotic is necessary to eliminate the bacteria from the patient's bloodstream.

    Usage

    Often contrasted with 'topical' or 'local' in medical contexts.

Usage systemic challenge

The show brilliantly dissects racism, from the sweeping and systemic to the petty and everyday.

The Guardian· 15 Aug 2026

By contrast, p-cresol sulfate and phenol sulfate come from tyrosine and have been linked to worse outcomes in cancer patients as well as systemic toxicity in people with kidney disease.

ScienceDaily· 15 Aug 2026

From system + -ic. Doublet of systematic.

Etymology adapted from Wiktionary, available under CC BY-SA 4.0.

This entry
Level C1 · Advanced
Frequency Frequent
Updated