English Reference
Adjective

degenerative

adj.
C1 Advanced US /dɪˈdʒɛnɝətɪv/ UK /dɪdʒˈɛnəɹətˌɪv/ de·gen·er·a·tive

adj.describing a disease or physical condition that gets worse over time. It is often used to talk about health problems that affect the brain or body as people get older.

adj.characterised by progressive, often irreversible deterioration of cells, tissues, or organs. Often used in medical contexts to describe chronic conditions that result in a loss of function.


SIMPLE

Arthritis is a degenerative disease that affects the joints.

CONTEXTUAL

Doctors are researching new treatments to slow down the degenerative effects of the condition on the patient's nervous system.

COMPLEX

While some injuries heal with rest, degenerative conditions require long-term management strategies to maintain the patient's quality of life as the underlying structures continue to weaken.

Usage

Typically used attributively before a noun like 'disease', 'condition', or 'process'.

In degenerative eye diseases, although the photoreceptors are lost, much of this underlying circuitry remains intact but inactive.

ScienceDaily· 28 Aug 2026

A new study says at least one in four ex-NFL players who died between 2016 and 2021 had a degenerative brain disease but the true figure could be much higher.

BBC News· 25 Aug 2026

From degenerate + -ive.

Etymology adapted from Wiktionary, available under CC BY-SA 4.0.

This entry
Level C1 · Advanced
Frequency Occasional
Updated