exhaustion
n. uncountablen. the state of being extremely tired or having no energy left. It can also mean using up all of a supply of something until nothing remains.
n. the state of extreme physical or mental fatigue; also refers to the action of completely consuming or depleting a resource.
She collapsed onto the sofa in total exhaustion.
After working three double shifts in a row, the medical staff suffered from severe physical and mental exhaustion.
The rapid exhaustion of the region's natural resources led to a significant economic downturn as industries struggled to find alternative materials.
Borrowed from Medieval Latin exhaustiō, from exhauriō. Surface analysis: exhaust + -ion.
Often used with the preposition 'of' when referring to the depletion of resources.