profound
adj.adj. showing great knowledge or deep thought. You use it to describe something that has a very big effect or a deep meaning.
adj. showing or requiring great insight or intellectual depth; having a significant and far-reaching impact on a situation or person.
The book had a profound effect on my life.
The discovery of the new medicine had a profound impact on how doctors treat the disease.
The philosopher's latest work offers a profound meditation on the nature of consciousness, challenging several long-held assumptions in the field of cognitive science.
From Middle English profound, profounde, from Anglo-Norman profound, from Old French profont, profonde, from Latin profundus (“deep, profound”), from prō + fundus (“bottom; foundation”).
Commonly modifies abstract nouns like 'impact', 'effect', 'change', or 'influence'.